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A Comparison of the Retardation of Sarcoma 180 by SK 1424, 3-Bis(ß-chloroethyl)aminomethyl-4-methoxymethyl-5-hydroxy-6-methylpyridine with That by HN2, Methylbis(ß-chloroethyl)amine^{* ,}

( Division of Experimental Chemotherapy, The Sloan-Kettering Institute for Cancer Research, New York 21, N.Y.)

A nitrogen mustard, SK 1424, has been found which appears to be more efficient in retarding Sarcoma 180 than HN2, the nitrogen mustard used as our standard.

^* We wish to acknowledge support of this study by funds from the American Cancer Society.

With the technical assistance of Margaret L. Keeve and Angela T. Boryczka.

Received 1/12/51.