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The Effect of Complete Ablation of Thyroid Tissue by Radioactive Iodine on the Survival of Tumor-bearing Mice^*

( Harrison Department of Surgical Research, School of Medicine, University of Pennsylvania, Philadelphia, Pa.)

1. Ablation of thyroid tissue in mice bearing transplanted fibrosarcomas has been carried out by administration of radioactive iodine (I¹³¹). This ablation was done both prior to and after implantation of the tumors.

2. The average rate of growth of the tumors and the average period of survival of the mice in which thyroid tissue had been ablated were not significantly different from those of untreated tumor-bearing mice.

3. It is concluded that thyroid ablation has no significant effect on tumor growth.

^* Aided in part by a grant to Dr. Margaret R. Lewis from the National Cancer Institute, Public Health Service.

Received 1/25/51.