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The Development of Mammary Cancer in Castrate A Strain Male Mice Bearing Ovarian Grafts^*

( Division of Cancer Biology of the Department of Physiology, University of Minnesota Medical School, Minneapolis 14, Minn.)

Forty per cent of a group of castrate A strain male mice bearing subcutaneous ovarian grafts developed mammary carcinoma at an average age of 14.8 months. Only 4 per cent of virgin female mice of this strain developed mammary cancer at an average age of 15.0 months, while during the period of this experiment 80.5 per cent of breeding females were afflicted at an average age of 11.7 months. It is, therefore, evident from these and other experiments that the tendency for castrate male mice bearing transplanted ovaries to have mammary cancer is intermediate between that noted in virgin and in breeding mice of the same stock. A study of the mammae of these male mice revealed them to be considerably more developed than those of virgin A strain mice, in that they possessed much more lateral budding, frequently contained considerable secretion in their ducts, and had areas of normal-appearing alveolae as well as typical areas of precancerous nodular hyperplasia.

^* Assisted by grants from the Minnesota Cancer Society, the American Cancer Society upon recommendation of the Committee on Growth of the National Research Council, the Graduate School Research Fund of the University of Minnesota, and the National Cancer Institute of the National Institute of Health, Public Health Service.

Received 2/ 1/51.