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Tumor Production in Rats Injected Intravenously with Oil Emulsions Containing 9,10-Dimethyl-1,2-Benzanthracene^*

(The Department of Nutrition, Harvard School of Public Health, Boston 15, Mass.)

The intravenous administration of fat emulsions which contained 9,10-dimethyl-1,2-benzanthracene caused a high incidence of skin tumors in female rats of the Sprague-Dawley strain. Fifty-five per cent of the surviving animals developed keratinizing squamous-cell tumors of the sebaceous gland type and/or adenocarcinomas which were usually located over the course of the "mammary line" on the ventral surface of the trunk. Only two animals developed neoplasms which were not of skin or dermal adnexae derivative.

^* Supported in part by grants-in-aid from the National Cancer Institute of the National Institutes of Health, Public Health Service, the Nutrition Foundation, Inc., New York, N.Y., and The American Cancer Society.

Received 2/19/51.

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