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Effect of Pyridoxine and Desoxypyridoxine on Rat Fibrosarcoma Grafts^*

( Foundation of Applied Research, San Antonio, Texas)

The incidence of fibrosarcomas, following subcutaneous grafting into 7-week-old control rats living on a Purina Laboratory Chow diet, was compared to that in rats which received supplements of pyridoxine and in others that were given desoxypyridoxine; 243 animals were used.

Pyridoxine supplements per rat totaled as much as 1,500 µg. over a 2-week period before implantation and up to 400 µg. following grafting. Desoxypyridoxine injections totaled as much as 110 mg. per rat preceding tumor injections and up to 40 mg. subsequently.

Tumor takes after 13–20 days in pyridoxinetreated rats averaged 40 per cent, as compared to takes of 16 and 11 per cent, respectively, in controls and desoxypyridoxine-treated animals. Pyridoxine deficiency symptoms were noted in only a few rats bearing tumors in the desoxypyridoxine-treated group.

Although this analog was also administered in relatively large amounts to nontumor-bearing hamsters on an identical basic diet over a period of 59 days, no vitamin B₆ deficiency symptoms were observed.

^* Supported in part by grants-in-aid from Mr. and Mrs. Lewis J. Moorman, Jr., and the American Cancer Society (#CBC5).

Received 8/ 7/50.