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Studies on the Carbohydrate and Protein Metabolism of the Rat Hepatoma^*

( Medical Laboratories of the Collis P. Huntington Memorial Hospital of Harvard University, Massachusetts General Hospital, Boston, Mass.)

These experiments fail to disclose any qualitative differences in metabolic pathways followed by the neoplastic and normal hepatic tissues. They do appear to imply that the synthetic activities of the hepatoma slice are adjusted more toward construction of molecules such as proteins which are immediately concerned with cell growth than toward storage of energy-rich material such as glycogen for future use. The previous inability to correlate in vitro and in vivo experiments on amino acid incorporation into protein has been related to a circulatory impairment of the tumor in the living animal.

^* This is publication 738 of the Harvard Cancer Commission. This work was supported by grants-in-aid from the American Cancer Society and the Atomic Energy Commission.