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The Nature of the Fatty Acids of Rats Growing Walker Carcinoma 256^{* ,}

( Department of Biochemistry, University of Rochester School of Medicine and Dentistry, Rochester, N.Y.)

1. Rats bearing Walker carcinoma 256 and rats without tumors that ate the same amount and kind of diet containing either Crisco or elaidin were compared with respect to: (a) total lipid content of blood plasma and carcass and (b) amount and degree of unsaturation of solid and liquid fatty acids.

2. The total lipid content of the blood plasma was higher, while that of the carcass was lower in rats with tumor. The rise in blood lipids occurred early in tumor growth.

3. In rats with small tumors, the nature of the fatty acids of the carcass differed markedly from that of the tumors and was closely similar to that of the controls.

4. In rats with large tumors, the fatty acids of the carcass were closely similar qualitatively to those of the tumor and significantly different from those of the pair-fed controls.

5. The degree of unsaturation of the liquid fatty acids was greater in carcasses of tumor-bearing rats than in controls.

6. In the carcass of the tumor-bearing rat the degree of unsaturation of the liquid fatty acids was inversely related to the fatty acid content of the rat.

7. In brief, the effect of the growing tumor on the host seems to be (a) to cause a lipemia, (b) to decrease the fatty acid content of the host, (c) to cause the ratio of solid to liquid fatty acids to become like that in tumor, and (d) to increase the degree of unsaturation of the liquid acids of the host.

^* This investigation was supported by a research grant from the National Cancer Institute, of the National Institutes of Health, Public Health Service; by a grant from the Jane Coffin Childs Memorial Fund for Medical Research; and by a grant from the Fluid Research Fund of the University of Rochester School of Medicine and Dentistry.

Presented in part at the Meeting of the American Association for Cancer Research, Inc., Cleveland, April, 1951.

Received 2/18/51.