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Effects of Anterior Hypophyseal Transplants on Intrasplenic Ovarian Grafts^*

( Snodgras Laboratory, Hospital Division, City of St. Louis, Mo.)

In ovariectomized mice of strain A, the effects of subcutaneous anterior hypophyseal transplants on intrasplenic ovarian grafts were studied. The hypophyseal transplants promoted growth and age changes in the grafted ovaries: proliferation of follicles and lutein tissue was stimulated; epithelial tubules and old lutein tissue appeared prematurely and were increased in amount; intrasplenic tumors tended to appear early; and the ratio of granulosa-cell tumors to luteomas shifted in favor of the latter. These effects are considered to be caused by the action of both the follicle-stimulating and luteinizing hormones given off by the grafted hypophyses.

^* This investigation was supported by a research grant from the National Cancer Institute, Public Health Service, and a grant from the Brant Fund of the American Medical Association.

Received 3/19/51.