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Differences in Immunologic Reactions of Red Blood Cells of a Tumor-susceptible (C3H) and a Tumor-resistant (C57) Mouse Strain^*

( Laboratory Division of Montefiore Hospital, New York, N.Y.)

1. Hemagglutination tests with red blood cells of normal mice and antitumor rabbit sera revealed a difference between C3H and C57 erythrocytes as to rate and degree of agglutination. A more or less transitory mid-zonal weak agglutination of C3H red blood cells was observed with serum dilutions in the range of 1:4 to 1:32.

2. Red blood cells of C3H mice with spontaneous breast tumor reacted differently than red blood cells of nontumorous C3H mice. They did not show the mid-zonal weak agglutination.

3. Mixtures of antitumor rabbit serum and tumor suspension agglutinated C3H and C57 red blood cells in a different manner. The C57 agglutination was weak initially and either persisted or gradually increased. The C3H agglutination varied widely.

4. Fresh materials such as tumor, erythrocytes, and possibly serum, as well as time and temperature, are important factors for the proper application of this hemagglutination test with antitumor sera.

^* Aided by a grant from the Damon Runyon Memorial Fund.

Received 2/16/51.