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Effect of Anti-viral Substances on the Mouse Mammary Tumor Milk Agent In vivo

( National Cancer Institute, Bethesda 14, Md.^*)

The effect of several anti-viral agents was studied in C3H mice containing the mammary tumor milk agent and in strain C mice given the agent during the course of treatment.

Aureomycin, chloramphenicol, and sodium phenosulfazole (Darvisul), when used in maximum tolerated doses, did not affect the tumor-producing properties of the milk agent.

Streptomycin did not influence the incidence of mammary tumors in the strains studied, but the mean tumor age was lowered in C mice given the mammary tumor milk agent.

^* National Institutes of Health, Public Health Service, Federal Security Agency.

Received 4/25/51.