This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Kaplan, H. S. Articles by Brown, M. B. Search for Related Content PubMed PubMed Citation Articles by Kaplan, H. S. Articles by Brown, M. B.

Inhibition by Testosterone of Radiation-induced Lymphoid Tumor Development in Intact and Castrate Adult Male Mice^*

( Department of Radiology, Stanford University School of Medicine, San Francisco, Calif.)

Intact and castrate male C57 black mice were irradiated and injected twice weekly for 10 weeks with an aqueous testosterone suspension; the corresponding litter-mate control groups were also irradiated and injected with a placebo of the suspension medium alone. Net lymphoid tumor incidence by groups was: (a) intact + x-ray + placebo, 39 of 52 mice (75 per cent); (b) castrate + x-ray + placebo, 45 of 52 mice (87 per cent); (c) intact + x-ray + testosterone, 4 of 49 mice (8 per cent); and (d) castrate + x-ray + testosterone, 5 of 50 mice (10 per cent). Some possible mechanisms for this pronounced inhibition are briefly discussed.

^* This investigation was supported by a grant from the National Cancer Institute, Public Health Service.

Received 4/28/51.