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A Mutation Producing Resistance to Several Transplantable Neoplasms in the C57 Black Strain of Mice

A new subline of mice (B10-x) was developed from the C57BL/10 strain (B10) by breeding animals which survived the inoculation with the C1498 leukemia, indigenous to the C57BL/6 strain. Whereas B10 mice are 100 per cent susceptible to this leukemia and to other neoplasms from the C57BL strain, the B10-x subline is 100 per cent resistant to the C1498 leukemia and to three out of four other transplantable tumors of the C57BL strain. Susceptibility or resistance to grafts of the C1498 leukemia is inherited according to Mendelian laws, a single gene being responsible for the fate of the inoculated leukemic cells. A mutation occurring in the original, susceptible strain affords the probable explanation for the origin of the isogenic resistant B10-x subline. Mutations affecting the histocompatibility genes can be easily detected by tumor transplantations.