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Effect of Neoplastic Tissue on the Turnover of Liver Nucleic Acids^*

( Donner Laboratory of Medical Physics, University of California, Berkeley, Calif.)

The rate of incorporation of P³² into DNA, nuclear PNA, and cytoplasmic PNA of liver tissue was measured in male A strain mice bearing transplanted mammary carcinoma, in female A strain mice bearing transplanted sarcoma A274, and in female C57 strain mice bearing a transplanted mammary carcinoma. An increase of P³² incorporation into the liver DNA was noted in all three groups of tumor-bearing mice when compared to the controls. A decrease in P³² incorporation into nuclear PNA was observed in the male A strain mice bearing mammary carcinoma. No significant difference in the rate of incorporation of P³² into the cytoplasmic PNA was observed in the tumor-bearing mice.

^* Partially supported by the United States Atomic Energy Commission.

Received 10/ 6/51.