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The Genesis and Growth of Tumors

V. Effects of Varying the Level of B Vitamins in the Diet^*

( Department of Cancer Research, Medical Research Institute, Michael Reese Hospital, Chicago 16, Ill.)

Four experiments on the influence of B vitamins in carcinogenesis were performed: two with spontaneous mammary carcinoma and two with carcinogen-induced skin tumors. Three groups of mice were employed in each study, and dietary thiamine, riboflavin, pyridoxine, pantothenate, niacin, and choline were varied, as a group, from levels just adequate for growth to 3, and 5 or 9 times these amounts. The rations were constructed of semipurified components, and the B vitamins were supplied by a yeast extract and, in larger proportion, by synthetic compounds. Caloric intakes and body weights were adequately controlled.

In each experiment, there were no significant differences in the incidence of tumors among the groups fed the minimal, moderate, or high levels of B vitamins. In three of the four experiments, however, the neoplasms developed at a faster rate in the mice ingesting moderate amounts of vitamins than in those on either low or high intake.

^* This investigation was supported by research grant C248 from the National Cancer Institute, of the National Institutes of Health, Public Health Service.

Supported, in part, by the Michael Reese Research Foundation and the Foundation for Cancer Research, Chicago.

Received 7/ 5/52.