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Studies on the Walker Tumor^*

II. Effects of Adrenalectomy and Hypophysectomy on Tumor Growth in Tube-fed Rats

Paul Talalay, G. M. V. Takano and Charles Huggins

( Ben May Laboratory for Cancer Research, University of Chicago, Chicago, Ill.)

1. Bilateral adrenalectomy in tube-fed rats maintained with saline drinking water inhibits the growth of intramuscular Walker tumor implants to ca. 57 per cent of controls.

2. Hypophysectomy in tube-fed rats inhibits the growth of intramuscular Walker tumor implants to ca. 46 per cent of controls.

3. Cortisone acetate or adrenal cortical extract in doses used can only to a slight extent counteract the absence of the adrenals or pituitary.

4. Combined removal of adrenals and pituitary results in a cumulative restraint on tumor growth.

^* This investigation was supported by grants from the American Cancer Society, upon recommendation of the Committee on Growth of the National Research Council, and the Jane Coffin Childs Memorial Fund for Medical Research.

Senior Assistant Surgeon, Federal Security Agency, United States Public Health Service.

Received 7/ 1/52.