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Effects of Combinations of Antileukemic Agents on an Acute Lymphocytic Leukemia of Mice^*

( The National Cancer Institute, Bethesda, Md.)

An approach to the problem of chemotherapy of experimental leukemia, based upon knowledge of the mechanism of resistance, is presented.

The effects of several antileukemic compounds on survival time of mice bearing the acute lyphocytic leukemia, L 1210, have been studied. Striking potentiating effects were found in leukemic mice given A-methopterin and 8-azaguanine simultaneously. Alpha-peltatin and triethylene melamine did not significantly influence the effects of the two antimetabolites.

A-methopterin and 8-azaguanine given simultaneously in combination were more effective than the two compounds given singly in combination.

Thirty-five out of 320 mice given combinations of antileukemic compounds simultaneously survived 90 days or longer. These mice were apparently nonleukemic, and all those reinoculated with leukemic cells proved to be susceptible.

^* Presented, in part, at the Gordon Research Conference, New London, N.H., August 30, 1951, and at the American Association for Cancer Research, Cleveland, Ohio, April 27–29, 1951.

National Institutes of Health, U.S. Public Health Service.

Received 7/14/52.