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Heterotransplantation of Human Cancer

II. Hamster Cheek Pouch^*

( Cancer Research Institute of the New England Deaconess Hospital, Laboratory of Pathology of the Harvard Cancer Commission, Boston 15, Mass.)

In the hamster cheek pouch, 30 of 65 human neoplasms persisted after heterologous transplantation (46 per cent). Second-generation transplantations were successful with eleven of twenty cancers, and third-generation growth in three of six cases. The method is relatively simple and appears to be of great potential value in growth studies of human cancer tissue. Treating host animals with stilbestrol or aureomycin or x-ray did not affect transplant survival.

^* This work was done under United States Atomic Energy Commission Contract AT(30-1)-901, at the New England Deaconess Hospital.

Received 9/ 2/52.