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The Effect of Heat Inactivation on Precipitation of Serum Proteins by Means of Sodium Chromate in Sera of Normal and Cancerous Subjects

( Department of Obstetrics and Gynecology, Stanford University School of Medicine, San Francisco, California)

A method of analysis, in which the difference in stability between the proteins of native and of heat-inactivated blood serum is determined with respect to sodium chromate, was applied to specimens of 230 noncancer cases and of 126 cancer cases. It was confirmed that this difference is significantly smaller in sera of cancer patients. Consideration of the extent of the deviation from normal values in connection with the affected organs showed that the stability difference decreases in the order: cancer of the cervix-endometrium-ovary, and to generally lower values in cancer of other internal organs. Analysis of sera of cancer patients who had received treatment and were considered clinically well showed continued cancer values in 17 out of 37 cases of cancer of the cervix, as against 1 out of 17 cases of cancer of the endometrium.

Received 8/25/51.