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Numerical Proportions of Different Cells in Mouse Epidermis during Early Methylcholanthrene Carcinogenesis^*

Banyen Davibhadhana

( Department of Anatomy, Division of Cancer Research, Washington University School of Medicine, St. Louis 10, Mo.)

1. The purpose of this investigation was to study the numerical proportions of different cells in mouse epidermis during methylcholanthrene carcinogenesis, for the purpose of obtaining some information on structural alterations that may condition the reported chemical changes.

2. Groups of Swiss albino mice were shaved and painted with methylcholanthrene in benzene with suitable controls and sacrificed at intervals up to 60 days. Counts were made of the proportions of basal, spinous, granular, dividing, and degenerating cells in the epidermis.

3. Methylcholanthrene induced a high degree of hyperplasia, an increased mitotic rate, and distinct cytological alterations. Basal and spinous cells were transformed to an altered type of spinous cells; granular cells also underwent a change to an altered type.

^* Aided by grants from the Charles F. Kettering Foundation and the American Cancer Society.

Data from a dissertation submitted to Washington University in partial fulfillment of requirements for the Ph.D. degree.

Present address: Department of Anatomy, Chulalongkorn Hospital, Bangkok, Siam.

Received 5/ 9/51.