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Incorporation and Turnover of Radiophosphorus in Mouse Mammary Tumors (dbrB and C3H)^*

( Biological Research Laboratory, Brooklyn College, N.Y., and the Cancer Research Laboratory, Department of Hospitals, City of New York, and the Department of Biology, Graduate School of Arts and Science, New York University, N.Y.)

Studies have been carried out on the incorporation and turnover of radiophosphorus into various fractions derived from the C3H and dbrB mouse mammary tumors, grown in the respective strains of mice. The results indicate again that the dbrB tumor has a higher rate of metabolic activity than the C3H tumor and substantiate those obtained from previous in vitro studies. It is concluded that these mouse mammary adenocarcinomas, although morphologically similar, exhibit significant differences in their physiological behavior.

^* This investigation is a phase of a project C-417 (C3) supported by grants obtained by one of the authors (A. G.) from the National Cancer Institute, National Institutes of Health, U.S. Public Health Service, and from the Damon Runyon Memorial Fund.

Received 8/21/51.