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Comparative Uptake of Free Amino Acids by Mouse-Ascites Carcinoma Cells and Normal Tissues^*

( Department of Biochemistry and Nutrition, Tufts College Medical School, Boston, Mass.)

When mice bearing the Ehrlich ascites tumor were fed glycine or L-alanine, the carcinoma cells were more active in the accumulation of the free amino acid than the cells of liver or muscle. This superiority in amino acid accumulation is considered a significant factor in the growth and multiplication of the neoplastic cell in a wasting animal.

^* Supported by grants from the National Cancer Institute of the National Institutes of Health, United States Public Health Service, and the Abbott Laboratories. The National Foundation for Infantile Paralysis kindly provided a shortterm predoctoral fellowship for one of us (M.E.H.).

Received 12/11/51.

This article has been cited by other articles:

				M. W. Noall, T. R. Riggs, L. M. Walker, and H. N. Christensen Endocrine Control of Amino Acid Transfer: Distribution of an Unmetabolizable Amino Acid Science, November 15, 1957; 126(3281): 1002 - 1005. [PDF]