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The Hyaluronidase Content of Necrotic Tumor and Testis Tissue^*

E. A. Balazs and J. von Euler

( Department of Experimental Histology, Karolinska Institutet, Stockholm, Sweden)

The hyaluronidase activity of the Walker rat carcinosarcoma and the Ehrlich mouse carcinoma was determined by the viscometric method. The rat carcinosarcoma showed HYAS activity but in varying amounts in different tumors. Dialysis and heat inactivation experiments showed that the activity was due to enzymes rather than depolymerizing substances of low molecular weight. In all cases the activity was greater in necrotic parts than in living parts of the tissues. Ehrlich carcinoma showed no activity at all. Comparison of HYAS activity in living and necrotic rat testes showed higher activity in necrotic tissue.

^* This work was supported by the Wenner-Gren Foundation.

Present address: Harvard Medical School, Dept. of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Mass.

Received 1/ 4/51.