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Electrophoretic Analysis of Plasma Protein Constitutents in Rats Bearing Regenerating and Pre-neoplastic Livers^*

( Research Laboratories, Montreal Cancer Institute, Notre Dams Hospital, Montreal, Canada)

Electrophoretic studies of plasma proteins were carried out during carcinogenesis by DAB, regeneration following partial hepatectomy, and during the combined processes of regeneration and carcinogenesis. The following results are noted:

1. In the three conditions there is a decrease in albumin and an increase in -globulin concentrations. In addition, however, the - and ß-globulins levels vary during regeneration. This difference in the protein pattern may lead to the conclusion that the period of carcinogenesis which has been studied is a period of liver damage and not of cell proliferation.

2. The results for the combined phenomena of regeneration and carcinogenesis indicate that the effects of regeneration mask the effects of DAB.

3. The maximum variations of albumin and -globulin concentrations in plasma occur at about 90 days. Other authors have reported variations in other substances at this period.

^* This research, which is part of Project No. 48, has been made possible by a grant from the National Cancer Institute of Canada.

Received 4/13/51.