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The Influence of Certain Variables on the Incidence of Gastric Neoplasia in Mice of the Br-S Strain^*

( Anatomy Department, Yale University School of Medicine, New Haven, Conn.)

Analysis of data accumulated since 1945 for the Br-S strain has been made. Litter seriation (at least through the seventh litter) shows no influence on incidence of gastric tumors or of methylcholanthrene-induced local tumors in this strain. Incidences of gastric tumors and of local tumors are practically independent, over-all coincidence values agreeing with calculations. However, the age at incidence of gastric tumors tends to be bimodal, with positive correlation of gastric and local tumor incidence in the earlier age group, negative in the later.

Marked fluctuations of gastric tumor incidences with time are demonstrated in Br-S mice. A striking drop at one period was limited to those mice receiving dietary supplements. Two other groups at this time fed only Nurishmix had as high an incidence as usual. One of these groups consisted of F₁ hybrids from the gastric tumor strain x C57 black.

Body weights show a significant correlation with gastric tumor incidence. Mice with such tumors have median body weights about 10–15 per cent greater than those lacking them.

The evidence favors an interpretation of variables in nutritional status, not yet analyzed, which are capable of completely suppressing gastric tumors in this strain.

^* This investigation was supported in part by a research grant from the National Cancer Institute of the National Institutes of Health, Public Health Service, and from The Jane Coffin Childs Memorial Fund for Medical Research and The Anna Fuller Fund.

Received 12/22/51.