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An Ultracentrifugal Analysis of the Macromolecular Particles of Normal and Leukemic Mouse Spleen

Mary L. Petermann and Mary G. Hamilton^*,

( Sloan-Kettering Institute for Cancer Research, New York, N.Y.)

The macromolecular nucleoprotein particles from the cytoplasm of normal and leukemic mouse spleen have been separated by differential centrifugation and analyzed in the ultracentrifuge. Several well defined sedimentation boundaries have been observed. They represent components whose concentration, either on a weight or on a per cell basis, is greatly increased in both transplanted and spontaneous leukemia.

^* The authors wish to acknowledge the assistance of the National Cancer Institute of the United States Public Health Service and the Atomic Energy Commission (Contract AT (30-1)-910).

Presented in part at the Forty-second Annual Meeting of the American Association for Cancer Research, Inc., Cleveland, Ohio, April 27–29, 1951 (Abstr., Cancer Research, 11:273, 1951).

Received 12/29/51.