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Effects of A-Methopterin (4-Amino-N¹⁰-methylpteroylglutamic Acid) on the Synthesis of the Adenine Moiety of Adenosine Triphosphate

( Biochemistry Division, Southern Research Institute, Birmingham, Ala.)

It has been demonstrated that formate and glycine are effective precursors of ATP adenine and that A-methopterin inhibits the synthesis of this nucleotide.

Received 1/ 5/52.