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The Effect of Neoplasia on the Turnover of Nucleic Acids Studied with Formate-C¹⁴ and Glycine-2-C¹⁴

( Donner Laboratory of Medical Physics, University of California, Berkeley, Calif.)

The incorporation of formate-C¹⁴ and glycine-2-C¹⁴ into DNA of liver, spleen, intestine, and tumor tissue and into cPNA of liver was measured, 4 hours after the administration of the precursor, in male A strain mice bearing transplants of mammary carcinoma or sarcoma A274. An increase in the specific activity was observed in the liver and spleen DNA of tumor-bearing mice as compared to the DNA of the same tissues from control mice. The specific activity of the DNA of the intestine was lower in all the tumor-bearing mice than the controls. The liver cPNA specific activity was essentially the same in the mice with tumor transplants as in the control mice.

^* Partially supported by the Atomic Energy Commission.

Received 1/21/52.

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