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Studies on a Transplantable Teratoma of the Mouse^*

( Roscoe B. Jackson Memorial Laboratory, Bar Harbor, Me.)

A spontaneously occurring ovarian teratoma containing undifferentiated "embryonic" and many types of differentiated tissue is described.

The tumor was transplanted subcutaneously and grew in males and females of the strain in which it originated (C3H_eB), in the C3H strain, and in F₁ hybrids of C57BL/6 x C3H.

The transplanted tumors maintained the pleomorphic character of the original tumor through nine serial transplants. It is considered that the essential elements of this tumor are the undifferentiated cells which are pluripotent. In giving rise to the differentiated tissues, the undifferentiated cells showed their potentialities and gave proof of their pluripotency.

^* This investigation was aided in part by the American Cancer Society upon recommendation of the Committee on Growth of the National Research Council and in part by the National Cancer Institute of the National Institutes of Health, Public Health Service.

Received 2/18/52.

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