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Protection against Radiation-induced Lymphoma Development by Shielding and Partial-Body Irradiation of Mice^*

( Department of Radiology, Stanford University School of Medicine, San Francisco, 15, Calif.)

Experiment 1.—Alternate half-body irradiation of C57 black mice yielded a maximal lymphoma incidence when the interval between treatment of the two body halves was 24 hours and decreased gradually thereafter through 8 days. Response was largely abolished when animals were irradiated first over the upper half of the body for four consecutive treatments and then similarly over the lower half of the body.

Experiment 2.—Lymphoma incidence was strikingly reduced by shielding the thigh, lower extremity, or lower abdomen, but not by shielding of the tail during irradiation. There was a suggestive relationship between the volume of tissue shielded and the degree of protection. Incidence was restored to normal high levels when the lower extremities were shielded initially and then locally irradiated either immediately or at an interval of 24 hours. There was no inhibition when a different extremity was shielded at each of four successive exposures.

^* This investigation was supported by a grant from the National Cancer Institute, National Institutes of Health, Public Health Service.

Received 2/24/52.

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				M. B. Brown, H. S. Kaplan, P. P. Weymouth, and J. Paull Effect of Intravenously Injected Bone Marrow Cell Suspensions on Thymic Regeneration in Irradiated C 57 Black Mice Science, June 19, 1953; 117(3051): 693 - 695. [PDF]