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Mitochondrial Population of Mammalian Cells

II. Variation in the Mitochondrial Population of the Average Rat Liver Cell during Regeneration. Use of the Mitochondrion as a Unit of Measurement^*

( Montreal Cancer Institute, Research Laboratories, Notre-Dame Hospital, Montreal, Canada)

1. The mitochondrial population of the average rat liver cell during regeneration was investigated by counting the mitochondria isolated from liver homogenates prepared in 0.25 M sucrose.

2. The population seemed to decrease in the average cell when the liver was in the process of stimulated growth after partial hepatectomy.

3. Possible chemical and physical changes in the average mitochondrion during regeneration of the liver have been discussed.

4. The mitochondrion as a unit for measurement of chemical constituents present in the mitochondrial fraction has been proposed as a more appropriate basis than other methods of expression.

^* This investigation is being supported by a grant from the National Cancer Institute of Canada.

Received 2/16/52.