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The Incorporation of Formate-C¹⁴, Glycine-2-C¹⁴, Adenine-4,6-C¹⁴, and Phosphate-P³² into Nucleic Acids

( Donner Laboratory of Medical Physics, University of California, Berkeley, Calif.)

The incorporation of formate-C¹⁴, glycine-2-C¹⁴, adenine-4,6-C¹⁴, and inorganic phosphate (P³²) into liver nucleic acids, splenic DNA, and intestinal DNA has been measured in adult male A strain mice under identical experimental conditions. The liver cPNA:DNA, nPNA:cPNA, spleen DNA:liver DNA, and intestine DNA:liver DNA specific activity ratios observed with the four labeling agents have been compared. From the observed results it is concluded that there is not an independent turnover of any one fraction of the nucleic acid molecule.

Received 5/ 8/52.