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The Inhibition of Liver Carcinogenesis with 3'-Methyl-4-dimethylaminoazobenzene in Hypophysectomized Rats^*

( Division of Biochemistry, School of Medicine, Stanford University, Stanford, Calif.)

Hypophysectomy effectively inhibited the formation of liver damage and hepatomas in rats fed diets containing 0.06 per cent 3'-methyl-4-dimethylaminoazobenzene up to periods of 19 weeks. In other experiments a 10–12-week period of feeding has usually been sufficient to induce a high percentage of tumors in intact animals.

^* This investigation was supported by a research grant from the Dernham Trust Fund, California Division, American Cancer Society.

Received 10/ 2/52.