This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Yokoyama, H. O. Articles by Stowell, R. E. Search for Related Content PubMed PubMed Citation Articles by Yokoyama, H. O. Articles by Stowell, R. E.

Regeneration of Mouse Liver after Partial Hepatectomy^*

Hisako O. Yokoyama, Margaret E. Wilson, Kenneth K. Tsuboi and Robert E. Stowell

( Department of Pathology and Oncology, University of Kansas Medical Center, Kansas City 12, Kansas)

Extirpation of 65 per cent of the mouse liver results in rapid growth of the remaining lobes, so that the original mass, in terms of percentage of liver to body weight, is essentially restored by the sixth day. However, the original total liver weight, nitrogen, and desoxyribonucleic acid are not completely recovered until the eighth day. The total number of nuclei increases more slowly and reaches 87 per cent of the normal value at 28 days after hepatectomy.

Parenchymal nuclei comprise only 56 per cent of the total nuclei of normal mouse liver, the remainder belonging to bile duct, Kupffer, connective tissue, smooth muscle, and mesothelial cells and also to macrophages and leukocytes. These nonparenchymal elements are increased between the third and 45th days of regeneration.

Substantial individual variation is observed in the response of mice to partial hepatectomy. The time interval after operation is not a satisfactory, uniform criterion of the degree of restoration of the liver remnant in individual mice.

^* Aided by grants from the National Cancer Institute, U.S. Public Health Service, and the Atomic Energy Commission.

Present address: Department of Pathology, Northwestern University Medical School, Chicago, Ill.

Present address: Department of Anatomy, New York University College of Medicine, New York, N.Y.

Present address: College of Physicians and Surgeons, Columbia University, New York, N.Y.

Received 10/ 8/52.

This article has been cited by other articles:

				S. H. Robinson and G. Brecher Delayed Incorporation of Tritiated Thymidine into DNA Science, October 18, 1963; 142(3590): 392 - 393. [Abstract] [PDF]