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Free Amino Acid Content and Transaminase Activity of Lymphatic Tissues and Lymphosarcomas^*

(The University of Texas, M. D. Anderson Hospital for Cancer Research, Houston, Texas)

Quantitative measurements have been made of the amino acid content of four lymphosarcomas, a carcinosarcoma, and normal lymphatic tissues of rodents. The pattern was drastically altered in the neoplasms. The lymphosarcomas exhibit markedly elevated contents of alanine and glycine. Proline was also elevated in these tissues compared to the normal tissues. Diminutions were observed of aspartic, ethanolamine phosphoric ester, and glutamine. Measurements were also made of transaminase activity. The results were discussed in terms of the metabolic reactions which lead to the formation and utilization of these amino acids.

^* This investigation was supported by grants from the National Cancer Institute of the National Institutes of Health, Public Health Service, and the American Cancer Society.

Received 4/15/53.