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Lack of Effect of High Potency Arginase on Tumor Growth^*

( Department of Physiological Chemistry, University of California School of Medicine, Berkeley, Calif.)

An investigation has been carried out on the relation of arginine and the enzyme arginase to tumor growth. The more significant results obtained are as follows:

1. Contrary to previously published results, no statistically significant differences were found in the arginase activities of blood plasma, muscle, or liver between control and tumor-bearing mice.

2. Intraperitoneal injection of a large number of units of arginase induced a considerable but transient drop in the plasma arginine level and no significant changes in the arginine concentration of tumor or liver tissue. The arginase content of the blood plasma was greatly increased after the injection for a period of up to 24 hours, but tumor tissue showed only a comparatively small increase which lasted only for a few hours.

3. No persistent carcinostatic effects were observed on a spectrum of tumors by the continued injection of daily doses of a large number of arginase units.

^* Aided by Research Grants from the American Cancer Society (Institutional Research Grant No. 43 to the University of California Cancer Research Institute) and the Cancer Research Funds of the University of California.

Received 5/ 1/53.