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Metabolism of the DBA Mouse Ascites Thymoma^*

Hilton B. Levy, Harold M. Davidson, Robert W. Reinhart and Arthur L. Schade

( Overly Biochemical Research Foundation, New York, N.Y.)

Some metabolic characteristics of an ascites thymoma in DBA mice, as a function of the number of days after inoculation of the tumor into the host, have been determined. The weight/cell, volume/cell, and cell dry weight/ml of cell suspension rose to a maximum 6–8 days after inoculation and then declined. The amount of PNA/cell and of DNA/cell also showed a cyclic rise and fall. The R.Q., Q, and Q, increased with age, the latter reaching values as high as 83. The Q_o remained essentially constant during the course of the growth of the tumor. It is suggested that the ascites tumor undergoes a period of rapid proliferation, followed by a decline in growth rate.

^* This investigation was supported in part by a research grant from the National Cancer Institute of the National Institutes of Health, Public Health Service.

Present address: National Microbiological Institute, National Institutes of Health, Bethesda, Maryland.

Present address: Boston Dispensary, 25 Bennet Street, Boston 11, Mass.

Received 5/ 1/53.