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Studies on the Ehrlich Ascites Tumor

II. Oxidation of Hexose Phosphates^*

H. G. Williams-Ashman

( Ben May Laboratory for Cancer Research, University of Chicago, Chicago 37, Ill.)

Extracts of Ehrlich ascites tumor cells were shown to contain active glucose-6-phosphate and 6-phosphogluconate dehydrogenases which are specific for triphosphopyridine nucleotide. The activity of these enzymes is of the same order of magnitude as that of the isocitric dehydrogenase of these cells, but considerably less than that of the lactic dehydrogenase. No evidence for the presence of either glucose dehydrogenase or pyridine nucleotide transhydrogenase was obtained. Ehrlich ascites tumor cells possess powerful glutathione reductase activity.

Glucose-6-phosphate and 6-phosphogluconate dehydrogenase activities were also demonstrated in the ascitic plasma.

^* This investigation was supported by grants from the American Cancer Society upon recommendation of the Committee on Growth of the National Research Council and the Jane Coffin Childs Memorial Fund for Medical Research.

Scholar in Cancer Research of the American Cancer Society.

Received 5/25/53.