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[Cancer Research 13, 729-732, October 1, 1953]
© 1953 American Association for Cancer Research
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Nucleic Acid Content of Splenic Lymphocytes in Normal and Leukemic Mice*

M. L. Menten, M. Willms and W. D. Wright

( British Columbia Medical Research Institute, Vancouver, British Columbia)

1. The DNAP content per splenic lymphocyte of normal mouse spleens varied between 0.37 x 10-9 and 0.57 x 10-9 mg., with a mean value of 0.49 x 10-9 mg. This mean value is lower than that reported for the DNAP of the isolated nucleus of the mouse lymphocyte. Possible reasons for the difference are discussed. The RNAP content per lymphocyte varied between 0.16 x 10-9 and 0.26 x 10-9 mg., with a mean value of 0.20 x 10-9 mg.
2. The DNAP of splenic lymphocytes from leukemic mice varied between 0.66 and 0.72 x 10-9 mg. The RNAP varied between 0.29 and 0.49 x 10-9 mg. Possible reason for higher values in leukemic mice is briefly discussed.
3. Relationship of RNAP to DNAP has been shown graphically by plotting values of the two nucleic acids obtained for splenic lymphocytes of both normal and leukemic mice in a scatter diagram. From the plot five lines of regression were developed with coefficients of correlation with values of 0.30, 0.37, 0.45, 0.55, and 0.68. Also included are nucleic acid analyses on lymphocytes derived from two dogs and two human spleens. Inclusion of values of human lymphocytes adds a lower line of regression with a coefficient of correlation of 0.14. It is postulated that these values represent phases in the relationship of RNAP to DNAP under varying conditions within the cell.

* This work was carried out under a grant from the British Columbia Division of the Canadian Cancer Society.

Received 5/27/53.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Cell Growth & Differentiation
Copyright © 1953 by the American Association for Cancer Research.