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Nucleic Acid Content of Cells of Bone Marrow Aspirated from Patients with Leukemia^*

( British Columbia Medical Research Institute and the Vancouver General Hospital, Vancouver, British Columbia)

1. The average DNAP per cell for samples of bone marrow aspirated from sixteen patients with lymphocytic leukemia was 0.68 x 10^-9 mg. Similarly, the average cellular DNAP for fourteen patients with granulocytic leukemia was 0.82 x 10^-9 mg/cell. These values were considerably decreased following therapeutic x-radiation.

2. When the paired values of DNAP and RNAP per cell were plotted as points in a scatter diagram on a graph in which DNAP was abscissa and RNAP was ordinate, six lines of regression were developed whose coefficients of correlation were 0.28, 0.36, 0.45, 0.55, 0.69, and 0.85. These values correspond to those similarly derived for the lymphocytes of spleens of the C57BL mouse.

^* This study was carried out under a grant from the British Columbia Division of the Canadian Cancer Society.

Received 5/27/53.