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Passive Immunization of Mice in Parabiosis Against a Transplanted Lymphosarcoma^*

( Department of Anatomy, College of Medicine, University of Illinois, Chicago, Ill.)

A lymphosarcoma of strain C3H origin (Gardner lymphosarcoma, also known as 6C3HED) grew progressively when transplanted into CBA mice. When tumor regression was induced by x-radiation the mice were resistant to retransplantation of the same tumor. This resistance could be demonstrated up to 105 days after tumor regression and could be transmitted to previously susceptible animals of the same strain by parabiosis. Radiation effects per se may not have been responsible for producing the immune response, since 55 per cent of nonirradiated animals with rapidly growing tumors resisted a second tumor graft.

^* This investigation has been supported by grants from the National Cancer Institute of the National Institutes of Health, U.S. Public Health Service, and the American Cancer Society, upon recommendation of the Committee on Growth of the National Research Council.

Received 6/16/53.