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Metastatic Frequency of Spontaneous Mammary Carcinoma in Mice Following Biopsy and Following Local Roentgen Irradiation

( The Radium Centre, Copenhagen, Denmark)

Local roentgen irradiation of spontaneous mammary carcinomas in DBA mice with doses of 1,000–2,000 r considerably increased the incidence of pulmonary metastases, as compared to a control group (22.2 per cent against 5.4 per cent). This increased incidence of pulmonary metastases was due only to a small extent to a longer survival in this group, but primarily to a real increase in the metastatic tendency caused by the irradiation. Removal of biopsy specimens did not significantly increase the incidence of metastases (11.4 per cent, compared to 5.4 per cent in the control group).

Received 6/29/53.