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Pituitary and Adrenal Factors Involved in Azo Dye Liver Carcinogenesis

( Department of Biochemistry, Stanford School of Medicine, Stanford University, Calif. and Sloan-Kettering Institute for Cancer Research, New York, N.Y.)

1. Groups of hypophysectomized male rats, maintained on diets containing 3'-methyl-4-dimethylaminoazobenzene, were injected subcutaneously with ACTHAR, equine pituitary corticotrophin, cortisone, DOCA, testosterone, or saline.

2. After 21 weeks livers from the above rats treated with saline, DOCA, testosterone or cortisone were still normal in appearance. Cirrhosis and liver tumors were evident in the liver of the rats injected with the adrenocorticotrophin preparations.

3. Intact rats, fed the above diet, were treated with the same hormone preparations. One group of these animals was restricted to the same food intake as the hypophysectomized rats. Extensive cirrhosis and hepatomas were evident in all these groups after 13 weeks.

Received 6/ 8/53.