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Phospholipid and Protein-bound Phosphorus Synthesis in the Rabbit Papilloma^*

( Departments of Biochemistry and Bacteriology, University of North Dakota Medical School, Grand Forks, N.D.)

The phospholipid P and protein-bound P synthesis in the rabbit papilloma (virus, Shope) and skin have been measured with the aid of radioactive phosphorus. If the specific activity, relative specific activity, or relative radioactivity values are taken as a measure of the synthesis of these fractions, there is a significant increase in phospholipid P and protein-bound P in the papilloma (P < 0.01) when compared to normal skin.

The papilloma contained less lipid and more phosphorus in the acid-soluble and protein-bound fraction than did the skin.

^* This investigation was supported (in part) by a research grant from the North Dakota Cancer Society. The P³² used in these experiments was obtained from the National Laboratories, Oak Ridge, Tenn. on allocation from the U.S. Atomic Energy Commission.

Received 6/26/53.