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Effect of Thyroid Function on Tissue Metabolism of Tumor-bearing Rats^*

( Departments of Zoology, University of California at Los Angeles, and of Pharmacology, Medical College of Alabama and School of Dentistry, University of Alabama, Birmingham 5, Ala.)

Fibrosarcoma tissue grown in AXC Irish gray rats has been found not to respond metabolically to hypo- or hyperthyroidism, although it had no influence upon the changes in oxygen consumption of liver or kidney typical of these conditions. Physical encroachment of the tumor bulk upon the thorax apparently was responsible for lowering the metabolic activity of diaphragm. However, this tissue still responded to hypo- and hyperthyroidism. There appeared to be no marked changes in growth rate or cytological appearance of the tumors in the different states of thyroid function.

^* This work was carried out during the tenure of a Krichesky-Ponty Memorial Fellowship at the University of California.

Received 7/27/53.