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Studies on a Transplantable Chicken Lymphoma (RPL-12)

I. Pathological Changes Following Transplantation of the Tumor^*

( Viral and Rickettsial Research, Lederle Laboratories Division, American Cyanamid Company, Pearl River, N.Y.)

1. Inoculation of varying amounts of the RPL-12 lymphoma can lead to growth of a palpable tumor with subsequent regression or to growth progressing to the death of the bird.

2. Regression of the tumor is followed by resistance to subsequent challenge with the same tumor, which is greater than that of normal birds of the same age.

3. Two phases are recognizable in the life cycle of the implanted tumor cells. The first, a stage of progressive growth, is of 10–17 days' duration. The second, a stage of regression, is characterized by phagocytosis of apparently intact tumor cells, and is of 3–4 days' duration.

4. The nature of the local and distant host reaction to the implanted tumor is described, and the changes which occur in the lymphoid and plasma cell series are interpreted as the morphological manifestations of an immune reaction.

5. Inoculation of heat-killed tumor tissue is not followed by the changes in lymphoid and plasma cells which accompany a progressively growing tumor and does not give rise to any resistance to subsequent challenge with live tumor cells.

^* A preliminary report of this work was presented at the 44th Annual Meeting of the American Association for Cancer Research in Chicago, Illinois, April 9–11, 1953, and published in abstract form (7).

Received 6/26/53.

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