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The Effect of 2-Acetylaminofluorene on Growth and Composition of the Liver of the Rat^{* ,}

( Radioisotope Laboratory, Veterans Administration Hospital, and Department of Physiological Chemistry, University of Minnesota Medical School, Minneapolis, Minn.)

1. The effect of 11 per cent and 20 per cent casein diets on the inhibitory action of AAF on the growth of the rat was studied. Using pair-fed rats, it was found that AAF inhibits growth on the 11 per cent but not on the 20 per cent casein ration.

2. AAF caused enlargement of the liver on both diets. Determinations of the fat, nitrogen, and sulfur content of the liver indicated that the composition of the livers of rats which had consumed AAF differed significantly from the composition of the livers of normal rats. There was no evidence for a sulfur depletion of the livers of rats consuming AAF.

3. The significance of the results is discussed and compared to similar data obtained with DBA.

^* Reviewed in the Veterans Administration and published with the approval of the Chief Medical Director. The statements and conclusions published by the authors are the result of their own study and do not necessarily reflect the opinion or policy of the Veterans Administration.

Supported by a grant from the Minnesota Division of the American Cancer Society, Inc.

Received 7/29/53.