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The Carcinogenic Activity of Dihydroxybenzidine Further Investigations^*

(The Clayton Aniline Company, Limited, Clayton, Manchester 11, England)

Synthetic 3,3'-dihydroxybenzidine was fed to rats of the Slonaker strain at a concentration of 0.125 per cent in a normal basic diet of Ministry of Food rat cake 41.

Histological changes in the liver, including cirrhosis and hepatomas, adenocarcinoma of the colon, carcinoma of the sebaceous glands adjacent to the external auditory canal, and squamous-cell carcinoma of the stomach were present in a number of animals under investigation. In addition, neoplastic changes in the bladders were observed in three of seven animals surviving 30 weeks or more. These tumors of the urinary bladder consisted of one sessile papilloma and two keratinized squamous-cell carcinomas of the bladder wall.

These findings are discussed in relation to the results of Spitz and co-workers, and the possibility that in vivo oxidation is a prerequisite to carcinogenic activity within the bladder is suggested, in the light of the similarity of results of this series and those reported with 2-acetylaminofluorene and 1-hydroxy-2-aminonaphthol.

^* A summary of this paper was presented before the 2d International Congress of Biochemistry held in Paris, France, July 21–26, 1952.

Received 8/28/52.

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				J. H. WEISBURGER, E. K. WEISBURGER, and H. P. MORRIS Orientation of Biochemical Hydroxylation in Aromatic Compounds Science, March 15, 1957; 125(3246): 503 - 503. [PDF]