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The Effect of Hormonal Therapy of Prostatic Cancer on Serum Aldolase^*

( Department of Surgery, Division of Urology, University of Chicago, Chicago, Ill.)

1. A method is presented for the quantitative determination of the activity of advanced prostatic cancer by the measurement of serum aldolase. Twelve of sixteen patients with proved, untreated, advanced, prostatic cancer were found to have increased concentrations of serum aldolase. All but two of these patients responded to hormonal therapy by a decrease to normal range of serum aldolase. Increased serum levels of this enzyme were usually maintained if hormonal therapy failed to produce cancer remission. This effect is apparently independent of the endocrine system, surgery, serum acid phosphatase, or nutritional status of the patient.

2. There is no correlation between the concentration of serum aldolase and either the presence or the activity of early, nonmetastatic, prostatic cancer.

^* This investigation was aided by an American Cancer Society Institutional Grant and the Gerber Memorial Cancer League.

Received 8/28/51.