Cancer Research Meeting Calendar  Jordan
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online

[Cancer Research 13, 147-152, February 1, 1953]
© 1953 American Association for Cancer Research

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dunning, W. F.
Right arrow Articles by Segaloff, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dunning, W. F.
Right arrow Articles by Segaloff, A.

Strain Differences in Response to Estrone and the Induction of Mammary Gland, Adrenal, and Bladder Cancer in Rats

W. F. Dunning, M. R. Curtis and A. Segaloff*

( Department of Microbiology, Division of Research and Industry, University of Miami, Coral Gables, Fla.)

1. One hundred and seventy-six rats of four different inbred strains survived a minimum of 150 days after the implantation of an estrone pellet weighing 8–12 mg. in the subcutaneous tissues of the scapular region.
2. One hundred and fifty-nine rats of three of the same inbred strains survived a minimum of 150 days after the simultaneous implantation of two similar estrone pellets.
3. Absorption of the hormone was more rapid from two pellets than from one, and in two of the three strains tested the survival period of the rats with two pellets was only about half as long as for rats of the same strain with one pellet.
4. Mammary cancers developed in rats of three of the four inbred strains tested with one estrone pellet but not in so high a percentage of the rats as was observed for rats of the same strains treated with a similar dose of diethylstilbestrol.
5. The minumum and average latent period for the induced mammary cancers was considerably shorter in the rats with two estrone pellets than in rats of the same strain with one estrone pellet. The percentage of rats with induced mammary cancers was increased by the larger dose of estrone in one strain but not in the other because of the shortened survival period.
6. No mammary cancers were induced in rats of one strain by either dose of estrone. This was the same strain that proved to be resistant to the induction of mammary cancers by diethylstilbestrol.
7. The induced mammary cancers were classified as 84 papillary cyst adenocarcinomas and four squamous-cell cancers
8. Bladder calculi and cancer were a frequent finding in rats of the strain that proved to be resistant to the induction of mammary cancer and occurred in a small percentage of the estronetreated rats of the strain with the highest percentage of induced mammary cancer. Adrenal adenomas or cancer were most frequent in rats of the latter strain but occurred in a small percentage of the rats of each strain.

* Endocrine Research Laboratory, The Alton Ochsner Medical Foundation, and the Department of Medicine, Tulane University of Louisiana, New Orleans 15, La.

Received 9/25/52.


This article has been cited by other articles:


Home page
CarcinogenesisHome page
X. Ren, X. Zhang, A. S. Kim, A. M. Mikheev, M. Fang, R. C. Sullivan, R. E. Bumgarner, and H. Zarbl
Comparative genomics of susceptibility to mammary carcinogenesis among inbred rat strains: role of reduced prolactin signaling in resistance of the Copenhagen strain
Carcinogenesis, January 1, 2008; 29(1): 177 - 185.
[Abstract] [Full Text] [PDF]


Home page
Toxicol PatholHome page
K. Yoshizawa, A. Heatherly, D. E. Malarkey, N. J. Walker, and A. Nyska
A Critical Comparison of Murine Pathology and Epidemiological Data of TCDD, PCB126, and PeCDF
Toxicol Pathol, December 1, 2007; 35(7): 865 - 879.
[Abstract] [Full Text] [PDF]


Home page
Toxicol PatholHome page
T. Imazawa, A. Nishikawa, A. Todate, F. Furukawa, H. Onodera, K. Mitsumori, M. Hirose, and Y. Hayashi
Dual Effects of Prolonged ACTH Stimulation on 4-Hydroxyaminoquinoline 1-Oxide-Induced Adrenocortical Lesions in Rats
Toxicol Pathol, July 1, 2000; 28(4): 535 - 539.
[Abstract] [PDF]


Home page
Toxicol PatholHome page
A. N. Johnson
Comparative Aspects of Contraceptive Steroids--Effects Observed in Beagle Dogs
Toxicol Pathol, February 1, 1989; 17(2): 389 - 395.
[Abstract] [PDF]


Home page
Arch Intern MedHome page
J. M. Munoz, C. A. Gorman, L. R. Elveback, and J. R. Wentz
Incidence of Malignant Neoplasms of All Types in Patients With Graves' Disease
Arch Intern Med, June 1, 1978; 138(6): 944 - 947.
[Abstract] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1953 by the American Association for Cancer Research.