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The Combined Effects of Cortisone and Roentgen Radiation upon Natural and Induced Resistance to Homoiotransplantation of Mouse Leukemia, Line I_b^*

A. A. Werder, Jack Friedman, E. C. MacDowell and J. T. Syverton

( Department of Bacteriology and Immunology, University of Minnesota, Department of Radiology, University of Minnesota and Mt. Sinai Hospital, Minneapolis, Minn., and the Department of Genetics, Carnegie Institution of Washington Cold Spring Harbor, Long Island, N.Y.)

Two extrinsic agents, cortisone and ionizing radiation, were found to convert the naturally resistant status conferred by the genetic constitution of the test inbred mice into a state of susceptibility. Mice representative of three resistant inbred strains, BALB, A, and STOLI, and of the stock Swiss albino CFW strain, by the administration of cortisone and x-radiation singly and in combination, were made susceptible to the homoiotransplantation of lymphoid leukemia, line I_b, when tested within 24 hours. The two agents operated synergistically to potentiate the alterative effect that may result from the employment of either agent singly. Contrariwise, mice made resistant by actively induced immunization with leukemic cells were little affected by the administration of cortisone and x-radiation singly or in combination.

^* This investigation was supported in part by a research grant from the National Cancer Institute of the National Institutes of Health, Public Health Service.

Dept. of Bacteriology and Immunology, University of Minnesota.

Dept. of Radiology, University of Minnesota, and Mt. Sinai Hospital.

Carnegie Inst. of Washington, Cold Spring Harbor, Long Island.

Received 10/10/52.